One consideration that can affect many components in your home is the allergies of the people who live in it. The adjustments that can help depend on the item(s) causing the allergic reaction.
Allergies to dust, or more specifically dust mites, can be alleviated by reducing the things that can hold dust and additional cleaning. For instance, hardwood floors are easier to keep dust free than carpeted floors.
Allergies to food... if you need to have the food in the house, keep it away from other foods.
Pet allergies... surfaces that make it easier to clean up the hair... good vacuum cleaner.